Sickle cell anaemia is caused by a mutation that leads to the substitution of

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valine by glutamic acid at the 6^th position of alpha globin chain

glutamic acid by valine at the 6^th position of alpha globin chain

glutamic acid by valine at the 6^th position of beta globin chain

valine by glutamic acid at the 6^th position of beta globin chain

answer is A.

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Detailed Solution

Sickle cell anaemia is due to a point mutation involving the single base substitution at the sixth codon of the beta globin gene from GAG to GUG. This causes substitution of glutamic acid by valine at the 6^th position of beta globin chain.

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