Sickle cell anaemia results from the single amino acid substitution in the

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alpha chain of haemoglobin molecule.

beta chain of haemoglobin molecule.

delta chain of haemoglobin molecule.

alpha as well as beta chains of haemoglobin molecule.

answer is B.

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Detailed Solution

Sickle cell anemia is an autosomal recessive disorder. The defect is caused by the substitution of Glutamic acid (Glu) by Valine (Val) at the sixth position of the beta globin chain of the haemoglobin molecule.

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