State whether the statement is true/false:

The distinct regions of the endoplasmic reticulum include the rough endoplasmic reticulum (RER) and the smooth endoplasmic reticulum (SER).

The given statement is true.

The endoplasmic reticulum (ER) is a membrane-bound organelle found in eukaryotic cells. It is divided into two distinct regions based on the presence or absence of ribosomes on its surface:

1. Rough endoplasmic reticulum (RER) - It has ribosomes attached to its surface, giving it a rough appearance. RER is responsible for the synthesis, folding, and modification of proteins that are destined for secretion, and insertion into membranes or other organelles.
2. Smooth endoplasmic reticulum (SER) - It lacks ribosomes on its surface, making it appear smooth. SER is involved in lipid metabolism, including the synthesis of steroid hormones and the detoxification of drugs and toxins.