Statement-I : The bond between drug and enzyme can never be a strong covalent bond.

Statement-II: Binding of inhibitor to allosteric site of enzyme facilitates the attack of substrate on active site of enzyme.

I) The bond between enzyme and drug can be a strong covalent bond and  cannot be broken easily. In such cases the enzyme is blocked permanently.

II) Binding of inhibitor (drug) at allosteric site changes the shape of active site of enzyme such a way that substrate cannot recognize it.