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Thalassemia and sickle cell anaemia are caused due to a problem in globin molecule synthesis. Select the correct statement.

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Both are due to a quantitative defect in globin chain synthesis.

Thalassemia is due to less synthesis of globin molecules.

Sickle cell anaemia is due to a quantitative problem of globin molecules.

Both are due to a qualitative defect in globin chain synthesis.

answer is B.

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Detailed Solution

In α-Thalassemia, production of α globin chain is affected while in β-Thalassemia, production of β globin chain is affected.

Alpha globin chain is controlled by two linked genes present on the chromosome 16, while beta globin chain is controlled by a single gene present on the chromosome 11.

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