The binding of CO₂ to haemoglobin is primarily related to

The binding of CO₂ to haemoglobin is primarily related to the partial pressure of CO₂. pO₂ is a major factor which could affect this binding. At the tissues where pCO₂ is high and pO₂ is low, more binding of carbon dioxide occurs. At the alveoli where the pCO₂ is low and pO₂ is high, dissociation of CO₂ from carbamino-haemoglobin takes place and CO₂ is delivered to the alveoli.