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The calculation of the net gain of ATP for every glucose molecule oxidized is based on the following assumptions.
a)There is a sequential, orderly pathway functioning, with one substrate forming the next and with glycolysis, TCA cycle and ETS pathway following one after another.
b) The FADH₂ synthesized in glycolysis is transferred into the mitochondria and undergoes oxidative phosphorylation.
c) None of the intermediates in the pathway are utilized to synthesize any other compound.
d) Only glucose is being respired – no other alternative substrates are entering the pathway at any of the intermediary stages.
Which of the following assumptions is/are correct?

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a,b and d only

a,b and c only

b,c and d only

a,c and d only

answer is D.

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Detailed Solution

FADH₂is formed only during krebs cycle.So statement b is incorrect.

During aerobic respiration, NADH₂is formed at two different locations. In the cytoplasm (glycolysis) and mitochondrial matrix (link reaction and Krebs cycle). All the NADH₂ formed should be fed into ETC for the complete yield of ATP.

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