The concentrated filtrate gets diluted in the ____ of the nephron.

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ascending limb of Henle’s loop

descending limb of Henle’s loop

descending limb of vasa recta

collecting duct

answer is A.

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Detailed Solution

The concentration of the glomerular filtrate reaches the maximum (1200 mOsmL^-1) at the hairpin loop of Henle's loop. As the filtrate moves through the ascending limb of Henle's loop, electrolytes are reabsorbed (passively and actively). Water is not reabsorbed since ascending limb of Henle's loop is impermeable to water. As a result, the filtrate gets diluted in the ascending limb.

The descending limb of Henle's loop is permeable to water and nearly impermeable to electrolytes. Hence the filtrate gets concentrated from 300 mOsmL^-1 to about 1200 mOsmL^-1 in the descending limb.

The filtrate doesn't pass through the vasa recta. The blood gets concentrated in the descending limb of vasa recta due to the entry of NaCl and exit of water.

The filtrate gets concentrated in the collecting duct from 300 mOsmL^-1 to about 1200 mOsmL^-1.

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