The enzyme pyruvate dehydrogenase helps in conversion of

Pyruvate, which is formed by the glycolytic catabolism of carbohydrates in the cytosol, after it enters mitochondrial matrix undergoes oxidative decarboxylation to form acetyl CoA by a complex set of reactions catalysed by pyruvic dehydrogenase. The reactions catalysed by pyruvic dehydrogenase require the participation of several coenzymes, including NAD+ and Coenzyme A.

$\mathrm{Pyruvic} \mathrm{acid} + \mathrm{CoA}+ {\mathrm{NAD}}^{+\stackrel{\mathrm{Pyruvate} \mathrm{dehydrogense}, {\mathrm{Mg}}^{+}}{\to }} \mathrm{Acetyl} \mathrm{CoA}+ {\mathrm{CO}}_2+\mathrm{NADH}+{\mathrm{H}}^{+}$