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Q.

The gradient of medullary interstitium is mainly caused by

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a

sodium chloride and urea

b

urea and HCl

c

urea and uric acid

d

urea and hydrogen ion

answer is A.

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Detailed Solution

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One of the main functions of the kidneys is to keep the solute load of body fluids constant by regulating urine concentration and volume. The kidneys accomplish this task using countercurrent mechanisms. They depend on active transportation of solutes out of the ascending limb of the loop of Henle.

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The gradient of medullary interstitium is mainly caused by