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The Hardy-Weinberg principle cannot operate if

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free interbreeding occurs among all members of the population

the population is very large

frequent mutations occur in the population

the population has no chance of interaction with other populations

answer is B.

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Detailed Solution

Mutation is one of the five factors (apart from gene flow, genetic drift, genetic recombination, natural selection) that affects Hardy-Weinberg equilibrium.

Large population, random mating or absence of gene migration does not disturb Hardy-Weinberg equilibrium.

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