The main bonding responsible for blockage of enzyme is

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ionic bond

van der Waals attractions

strong covalent bond

hydrogen bond

answer is D.

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Detailed Solution

The main bonding responsible for blockage of enzyme is typically a strong covalent bond.
In many cases, enzymes can be inhibited or blocked by the formation of a covalent bond between the inhibitor molecule and a functional group on the enzyme.
This covalent bond can form through a variety of mechanisms, including nucleophilic attack, Schiff base formation, and Michael addition, among others.
Once the bond is formed, it can effectively "lock" the enzyme in an inactive state, preventing it from catalyzing reactions.
While other types of bonds, such as hydrogen bonds, ionic bonds, and van der Waals attractions, can also play a role in enzyme inhibition, they are typically not as strong as covalent bonds and are less likely to completely block the enzyme's activity.

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