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Q.

The mechanism of action of “Terfendine” (Seldane) is

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a

Activates the histamine receptor

b

Inhibits the secretion of histamine

c

Helps in the secretion of histamine

d

Inhibits the action of histamine receptor

answer is D.

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Detailed Solution

  • Terfenadine (sold under the brand name Seldane) is an antihistamine medication that works by blocking the H1 histamine receptor, which is responsible for mediating the allergic response in the body.
  • Histamine is a chemical released by the body's immune cells in response to allergens, which causes symptoms such as itching, sneezing, runny nose, and watery eyes. 
  • Histamine binds to and activates the H1 histamine receptor, leading to the release of other chemicals that cause the symptoms of an allergic reaction.
  • Terfenadine competes with histamine for binding to the H1 receptor, blocking its activation by histamine. 
  • This reduces the release of other chemicals that cause the symptoms of an allergic reaction, leading to a reduction in allergy symptoms.
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