The most powerful weapon used by the Spanish to conquer America during the 16th century was ____.

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Detailed Solution

The most powerful weapon used by the Spanish to conquer America during the 16th century was germs. Conquerors carried smallpox disease on their person. It was a devastating disease that, on average, killed 3 out of 10 people who got it. Once it was introduced, it spread into the continent even before the Europeans could reach there. It killed people and paved the way for conquest and colonisation. As Americans were isolated, they did not have immunity to the diseases which came from Europe because of their isolation.

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