The problem due to Rh- factor arises when the blood of two (Rh+ and Rh-) mix up.

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During pregnancy

Through transfusion

In a test tube

Both A and B

answer is D.

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Detailed Solution

Concept- Nearly 80% of people contain the Rh antigen, making them Rh-positive or Rh+. Rh antigens are located on the surface of RBCs. 20% of the remaining people are Rh-negative or Rh-.
An Rh-negative person receiving Rh-positive blood during a blood transfusion will develop antibodies against the Rh-positive antigens, which will result in major health problems for the recipient. Similar to this, if the mother and fetus have different Rh factors during pregnancy, the condition is known as Rh incompatibility, and there is a possibility that the fetus and infant would develop hemolytic illness.
Hence, the correct answer is option 4 - Both A and B.

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