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Q.

The short 22nd chromosome formed by reciprocal translocation of chromosomal segments is called

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a

Philadelphia chromosome

b

Didelphia chromosome

c

Trisomic chromosome

d

Edward’s chromosome

answer is A.

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Detailed Solution

The Philadelphia chromosome or Philadelphia translocation (Ph) is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly chronic myeloid leukemia (CML) cells). This chromosome is defective and unusually short because of reciprocal translocation, t(9;22)(q34;q11), of genetic material between chromosome 9 and chromosome 22, and contains a fusion gene called BCR-ABL1.

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