Q.

The structure of a peptide is given below 

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If the absolute values of the net charge of the peptide at pH = 2, pH = 6, and pH = 11 are |z1|, |z2| and|z3| respectively, then what is |z1| + |z2| + |z3| ?

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answer is 5.

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Detailed Solution

|z1| + |z2| + |z3| = 5
 

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At pH = 2 NH21 and NH22of tyrosine and lysine are positively charged (+1 each) +2 |z1| = 2
At pH = 6, NH2 of Lysine (+1), COOH (–1) of
glutamic aicd, so because of dipolar ion, |z2| = 0
At pH = 11, COOH of glutamic acid (–1)
COOh of phnol(–1)
OH of phenol (–1)
z3=3

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