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Q.

The structure of aspartic acid is given below 

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(A) .

 

The pKa1, pKa2, and pKa3 of (A), respectively, are:1.88, 3.65 and 9.60. pKa1 corresponds to the ionization of the COOH group, of

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. pKa2 corresponds to the ionisation of +NH3(ammonium ion). What is the pH at isoelectric points (pI)?

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a

pKa2+pK32

b

pKa1+pKa33

c

pKa1+pKa22

d

pKa1+pKa2+pKa33

answer is A.

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Detailed Solution

The pKa value indicates the strength of an acid. pKa is the negative log of the acid dissociation constant or Ka value. A lower pKa value indicates a stronger acid. If there are more than one carboxylic group then we will take the average of pKa of carboxyl groups pH=pKa1+pKa22Hence, the correct options is(1)

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The structure of aspartic acid is given below (A) . The pKa1, pKa2, and pKa3 of (A), respectively, are:1.88, 3.65 and 9.60. pKa1 corresponds to the ionization of the COOH group, of. pKa2 corresponds to the ionisation of +NH3(ammonium ion). What is the pH at isoelectric points (pI)?