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The toxic substance responsible for the chills and high fever associated with malaria is

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haemolysin

haemozoin

hypnotoxin

haemocyanin

answer is B.

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Detailed Solution

The toxic substance which is responsible for the chill and high fever associated with malaria is haemozoin, released from the ruptured RBCs.

Haemolysin is the anticoagulant in the saliva of mosquitoes.

Hypnotoxin is the poisonous fluid in the penetrant cnidocytes.

Haemocyanin is the blue-coloured respiratory pigment in molluscs and some arthropods.

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