Q.

The pKa of acetylsalicylrc acid (aspirin) is 3.5. The pH of gastric juice in human stomach is about 2-3 and the pH in the small intestine 1s about 8. Aspirin will be:

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a

unionised in the small intestine and in the stomach

b

completely ionised in the small intestine and in the stomach

c

ionised in the stomach and almost unisoni.sed in the small intestine

d

ionised in the stomach and almost unionised in the small intestine

answer is D.

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Detailed Solution

In the small intestine, bases can react with aspirin, however, human stomach is relatively acidic, hence, cannot ionise aspirin.

So, ionised in the stomach and almost unionised in the small intestine

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