Under which of the following conditions there will be no change in the reading frame of following mRNA?
5' AACAGCGGUGCUAUU 3'

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Deletion of GGU from 7th, 8th and 9th position

Insertion of G at 5th position

Deletion of G from 5th position

Insertion of A and G at 4th and 5th position respectively

answer is A.

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Detailed Solution

Genetic code is triplet.If we delete GGU from 7th , 8th and 9th position then the entire codon will be deleted. Hence there will not be any change in the reading frame.

Insertion of a single nucleotide alter the reading frame and will lead to frame shift mutation

Deletion of a single nucleotide alter the reading frame and will lead to frame shift mutation.

Addition of A and G will also alter the reading framing as genetic code is triplet.

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