Weisman cut off tails of mice generation after generation but tails neither disappeared nor shorted showing that 

The German biologist August Weismann (1834–1914) formulated the germ-plasm theory of inheritance. Weismann reasoned that reproductive cells (germ cells) were separate from the functional body cells (soma or somatic cells). Therefore, changes to the soma would not affect the germ-plasm and would not be passed on to the offspring. In order to prove that the disuse or loss of somatic structures would not affect the subsequent offspring, Weismann removed the tails of mice and then allowed them to breed. After twenty generations of this experimental protocol, he found that mice still grew tails of the same length as those who had never been manipulated. It disproved Lamarck’s theory of use and disuse (also inheritance of acquired characteristics).