Which five carbon intermediate of Krebs cycle would provide the carbon skeleton for the synthesis of glutamate by reductive amination in the presence of NADPH and glutamate dehydrogenase?

see full answer

Your Exam Success, Personally Taken Care Of

1:1 expert mentors customize learning to your strength and weaknesses – so you score higher in school , IIT JEE and NEET entrance exams.

An Intiative by Sri Chaitanya

Citric acid

Alpha keto glutaric acid

Oxalo succinic acid

Malic acid

answer is C.

(Unlock A.I Detailed Solution for FREE)

Best Courses for You

JEE

NEET

Foundation JEE

Foundation NEET

CBSE

Detailed Solution

In the Kreb's cycle, alpha-ketoglutaric acid is the precursor of succinyl-CoA, which is further metabolized to produce ATP and other intermediates. Alpha-ketoglutaric acid can be transaminated to form glutamate, a process that involves the transfer of an amino group from an amino acid (usually alanine or glutamine) to alpha-ketoglutaric acid.

Therefore, alpha-ketoglutaric acid is the intermediate of the Kreb's cycle that provides the carbon skeleton for the synthesis of glutamate by reductive amination in the presence of NADPH and glutamate dehydrogenase.

Watch 3-min video & get full concept clarity