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Q.

Which is the basis of genetic mapping of human genome as well as DNA finger printing?

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a

Polymorphism in hnRNA sequence

b

Polymorphism in DNA sequence

c

Single nucleotide polymorphism

d

Polymorphism in RNA sequence

answer is D.

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Detailed Solution

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Genetic mapping of the human genome and DNA fingerprinting both rely on polymorphisms in DNA sequences. Polymorphisms are variations in the DNA sequence that occur naturally in a population. These polymorphisms serve as markers that can be used to distinguish between individuals or to map the location of genes on chromosomes. In DNA fingerprinting, polymorphic DNA regions, such as variable number tandem repeats (VNTRs), are used as unique identifiers for individual identification.
(1) Single nucleotide polymorphisms (SNPs) are a specific type of DNA sequence variation where a single nucleotide (A, T, C, or G) differs between individuals. 
(2) hnRNA (heterogeneous nuclear RNA) refers to the precursor form of mRNA (messenger RNA) in eukaryotic cells. It undergoes processing, including splicing and modifications, to become mature mRNA, which is then translated into proteins. While hnRNA can have polymorphisms, these polymorphisms would not be suitable for genetic mapping of the human genome or DNA fingerprinting purposes. 
(3) RNA sequences can also show polymorphisms, but they are not typically used in the context of genetic mapping of the human genome or DNA fingerprinting. The primary focus is on DNA sequences due to their stability and central role in determining genetic traits.

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