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Q.

Which of the following best describes the process that converts heterogeneous nuclear RNA (hnRNA) into mature mRNA?

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a

Intron retention and exon skipping to ensure mRNA stability.

b

Addition of adenylate residues to the 5'-end and removal of exons.

c

Splicing to remove introns and joining of exons, along with capping at the 5'-end and tailing at the 3'-end.

d

Continuous synthesis of exons only, excluding introns from the primary transcript.

answer is C.

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Detailed Solution

In eukaryotes, the nascent/primary mRNA undergoes post-transcriptional modifications, which  includes splicing,capping and tailing.

Splicing: removal of introns and joining of exons.

5'capping : Adding a 7 methyl guanosine which acts as a protective cap

3' tailing: Adding hundreds of adenylate residues .

Both capping and tailing are enzyme catalysed but template independent.

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