Which of the following cannot be detected in a developing foetus by amniocentesis?

Amniocentesis is not typically used to diagnose jaundice in a foetus. Jaundice is a condition in which there is an accumulation of bilirubin in the blood, resulting in yellowing of the skin and eyes. It is usually diagnosed
after birth, based on physical examination and laboratory tests.

(1) Amniocentesis can be helpful in diagnosing Down’s syndrome by observing the chromosomes of the
foetal cells. Down’s syndrome is characterised by the presence of an extra copy of chromosome 21.

(3) Amniocentesis can be helpful in diagnosing Klinefelter’s syndrome by observing the chromosomes of the
foetal cells. Klinefelter’s syndrome is characterised by the presence of an extra X chromosome in male humans
(XXY).

(4) Amniocentesis can be used to determine sex of the foetus based on the allosomes present in the foetal cells (XX or XY). However, there are legal restrictions on this.