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Which of the following correctly describes the steps required to process hnRNA into mature mRNA?

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Removal exons and addition of a cap

Addition of a poly (A) tail at the 5’ end

Capping at the 3’ end only

Splicing to remove introns, template independent capping at the 5’ end with methyl guanosine, and adding a poly (A) tail at the 3’ end

answer is D.

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Detailed Solution

The steps required to process hnRNA into mature mRNA are as follows:

Splicing: Splicing involves the removal of introns and joining of exons in a defined order.

Capping: Capping involves addition of an unusual nucleotide (methyl guanosine triphosphate) to the 5'-end of hnRNA.

Tailing: Tailing involves addition of adenylate residues (200-300) at 3'-end in a template independent manner.

The fully processed hnRNA, now called mRNA, is transported out of the nucleus for translation

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