Which of the following diseases is caused by malfunctioning lysosomes?

The disease caused by malfunctioning lysosomes is Tay-Sachs disease. 

It is an inherited disorder that affects the breakdown of a type of lipid called ganglioside. A deficiency in the enzyme responsible for breaking down ganglioside leads to the accumulation of this lipid in the brain and nerve cells, causing damage to the nervous system. This disease is characterized by developmental delay, progressive weakness, seizures, and blindness, and ultimately leads to death in early childhood.