Q.

Which of the following hormone requires second messenger?

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a

Thyroxine

b

Cortisol

c

Androgens

d

Insulin

answer is D.

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Detailed Solution

Hormones which interact with membrane-bound receptors normally do not enter the target cell, but generate second messengers (e.g., cyclic AMP, IP3, Ca++ etc.) which in turn regulate cellular metabolism. 

Insulin is a peptide hormone that binds to membrane receptor.

Cortisol, androgens and thyroxine bind to intracellular receptors and so, do not require secondary messenger.

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