Which of the following hormones can play a significant role in osteoporosis?

Estrogen and parathyroid hormones play a significant role in osteoporosis. Osteoporosis is an age-related disorder characterised by decreased bone mass and increased chances of fractures. During the menopausal transition period, the drop of estrogen leads to more bone resorption than formation, resulting in osteoporosis.

Parathyroid hormone (PTH) is a hypercalcemic hormone that acts on bones and stimulates the process of bone resorption (dissolution/ demineralisation). So, hyperparathyroidism can lead to loss of bone mass and thus osteoporosis.

Aldosterone is a mineralocorticoid which maintains water electrolyte balance.

Prolactin helps in milk production.

Progesterone is a pregnancy hormone