Which of the following immune responses is responsible for rejection of kidney graft?

Kidney transplantation is a common treatment for patients with end-stage renal disease. However, the transplanted kidney may be recognized as foreign by the recipient’s immune system, leading to the rejection of the graft. The rejection is mainly due to cell-mediated immune responses.
(2) Autoimmune responses occur when the immune system mistakenly attacks the body’s own tissues. Transplanted kidney is not the patient’s own organ.
(3) Humoral immune responses involve the production of antibodies by B cells and are primarily responsible for defense against extracellular pathogens, such as bacteria.
(4) The inflammatory response is a nonspecific defense mechanism that occurs in response to tissue damage or infection. Inflammation is characterized by redness, swelling, warmth and pain at the site of injury or infection.