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Q.

Which of the following Mendelian disorder in humans is caused by the mutation of a gene on X chromosome?

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a

Haemophilia

b

Myotonic dystrophy

c

Cystic fibrosis

d

Thalassemia

answer is C.

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Detailed Solution

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Haemophilia is caused by the mutation of a gene on X chromosome. The mutant allele fails to synthesise a clotting factor due to which the blood does not clot normally, leading to prolonged bleeding or spontaneous bleeding.
Myotonic dystrophy is caused by a gene on chromosome 19. Cystic fibrosis is caused by mutations in the CFTR gene on chromosome 7. Beta thalassemia is caused by mutations in the HBB gene on chromosome 11. Alpha thalassemia is controlled by HBA1 and HBA2 genes on chromosome 16.
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