Which of the following statements are correct?
A. Basophils are most abundant cells of the total WBCs.
B. Basophils secrete histamine, serotonin and heparin.
C. Basophils are involved in inflammatory response.
D. Basophils have kidney shaped nucleus.
E. Basophils are agranulocytes.
Choose the correct answer from the options given below.

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A and B only

D and E only

B and C only

C and E only

answer is D.

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Detailed Solution

B and C are correct. A, D and E are incorrect.

A. Basophils are the least abundant leucocytes (WBC) and they constitute 0.5-1.0% of total WBC. The most abundant type of WBCs are neutrophils (60-65%).

B. Basophils secrete histamine, serotonin and heparin. Histamine and serotonin are involved in the inflammatory response, while heparin is an anticoagulant that helps prevent blood clotting.

C. Basophils are indeed involved in the inflammatory response. When activated, they release histamine and other inflammatory mediators that contribute to the inflammatory process.

D. Basophils have an irregularly lobed S-shaped or ribbon-shaped nucleus. Monocytes have a kidney-shaped nucleus.

E. Basophils are granulocytes. They have granules in their cytoplasm that contain various substances, including histamine and heparin. Lymphocytes and monocytes are agranulocytes while eosinophils, basophils and neutrophils are granulocytes.

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