Which of the following statements are correct about Klinefelter’s Syndrome?

A. This disorder was first described by Langdon Down (1866).

B. Such an individual has overall masculine development. However, the feminine development is also expressed.

C. The affected individual is short statured.

D. Physical, psychomotor and mental development is retarded.

E. Such individuals are sterile.

Choose the correct answer from the options given below.

B and E are correct. A, C, and D are incorrect.

Klinefilter’s syndrome is caused due to the presence of an additional copy of X chromosome, resulting in a karyotype of 47, XXY.

A. Down’s syndrome (mongolism) was first described by Langdon Down in 1866.

B. In Klinefelter’s syndrome, the affected individual has overall masculine development. However, the feminine
development is also expressed. This includes gynaecomastia (enlarged breast tissue).

C. The affected individual is short-statured in case of Turner’s syndrome.

D. In Down’s syndrome, there is typically a delay in physical, psychomotor and cognitive development.

E. Individuals exhibiting Klinefelter’s syndrome are usually sterile.