Which of the following statements best describes the difference between thalassemia and sickle cell anaemia?

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Thalassemia affects the production of only alpha chains of haemoglobin while sickle cell anaemia affects the production of only beta chains of haemoglobin.

Thalassemia is caused by a defect in WBCs while sickle cell anaemia is caused by a defect in RBCs.

Thalassemia is an autosomal dominant disorder while sickle cells anaemia is an autosomal recessive disorder.

Thalassemia is a problem of synthesising too few globin molecules while sickle cell anaemia is a problem of synthesising an incorrectly functioning globin.

answer is D.

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Detailed Solution

Thalassemia is a quantitative problem of synthesising too few globin molecules while sickle cell anaemia is a qualitative problem of synthesising an incorrectly functioning globin. Both are autosomal recessive disorders. Thalassemia can affect the production alpha chain (alpha thalassemia) or beta chain (beta thalassemia) while sickle cell anaemia affects only beta chain.

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