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Which of the following statements holds true for sickle cell anaemia but not for thalassemia?

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It is an autosomal recessive disorder.

It reduces the rate of synthesis of $α$ or $β$ chains of globin.

It is due to a mutation of the HBB gene of the 16^th chromosome.

Qualitative problem of synthesis of $β$ chain of globin.

answer is D.

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Detailed Solution

A point mutation of the HBB gene of the 11^th chromosome leads to an incorrectly functioning globin as the abnormal $β$ -chain has a valine at 6^th place.

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