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Q.

Which of the following statements is correct?

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a

The functional insulin has A and B chains linked together by disulphide bonds.

b

Insulin is synthesised as a pro-hormone in all mammals except humans.

c

Insulin can be administered orally as it is a protein hormone.

d

The proinsulin lacks C-peptide.

answer is D.

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Detailed Solution

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Insulin consists of two short polypeptide chains: chain A and chain B, that are linked together by disulphide bridges. 

Insulin is synthesised as a pro-hormone in all mammals including humans. 

Proinsulin contains an extra stretch called the C peptide. 

Insulin cannot be administered orally as it is a protein hormone and gets digested in the alimentary canal before being absorbed.

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