Which of the following statements is not true for cancer cells in relation to mutations?

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Mutations inactivate the cell control.

Mutations inhibit production of telomerase.

Mutations in proto-oncogenes accelerate the cell cycle.

Mutations destroy telomerase inhibitor.

answer is B.

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Detailed Solution

Mutations do not inhibit production of telomerase in cancer cells.

Telomeres, the protective structures of chromosome ends are gradually shortened by each cell division, eventually leading to senescence or apoptosis. Cancer cells maintain the telomere length for unlimited growth by telomerase reactivation or a recombination-based mechanism. In the large majority of cancer cells, telomere length is maintained by telomerase. Thus, telomere length and telomerase activity are crucial for cancer initiation and the survival of tumors.

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