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Q.

Which one of the following statements is incorrect ?

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a

The presence of the competitive inhibitor decreases the Km of the enzyme for the substrate

b

A competitive inhibitor reacts reversibly with the enzyme to form an enzyme inhibitor complex

c

In competitive inhibition, the inhibitor molecule is not chemically changed by the enzyme

d

The competitive inhibitor does not affect the rate of breakdown of the enzyme substrate complex

answer is A.

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Detailed Solution

The presence of competitive inhibitor decreases the affinity of the substrate to binding site of the enzyme which results in increase of Michaelis-Menten constant (km). Competitive inhibitor resembles closely with the substrate and competes for the active binding site of the enzyme.

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