Which type of substance would face difficulty to pass through the cell membrane?

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A substance with hydrophobic moiety

A substance with hydrophilic moiety

All substances irrespective of hydrophobic and hydrophilic moiety

Substance soluble in lipids

answer is B.

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Detailed Solution

Cell membranes are selectively permeable barriers that regulate the movement of substances in and out of the cell. The cell membrane is composed of a lipid bilayer with embedded proteins. The lipid bilayer creates a hydrophobic interior that is impermeable to hydrophilic substances.
(1) Hydrophobic substances can easily pass through the cell membrane due to their affi nity for the lipid bilayer.
(3) Hydrophobic moieties can easily pass through plasma membrane, but hydrophilic moieties fi nd it diffi cult to
move through plasma membrane.
(4) Substances soluble in lipids (hydrophobic substances) would not face diffi culty passing through the cell membrane, as they can readily dissolve in the lipid bilayer.

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