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Why does mental retardation occur in phenylketonuria?

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Tyrosine is not essential for synthesis of neurotransmitters in brain

Accumulation of phenyl pyruvic acid is toxic to brain

Accumulation of phenyl acetate in sweat and urine.

Tyrosine is essential for synthesis of melanin.

answer is C.

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Detailed Solution

Due to absence of phenylalanine hydroxylase, phenylalanine is not converted into tyrosine. Accumulation of phenylalanine and its derivatives is toxic to brain and causes mental retardation.

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