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Q.

Write a brief note on the structure of glucose

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Detailed Solution

Molecular formula of Glucose is C6H12O6 Glucose has two kinds of structures i.e., open chain, cyclic structures.
 Evidences in favour of open chain structure :

S.No.ReactionReagentProductConclusion
1)AcetylationAc2O/AcOHPenta acetatePresence of 5–OH groups
2)With Hydroxyl amineNH2OHOximePresence of Question Image
3)Mild oxidationBr2/ H2O or Gluconic acid Presence of –CHO
Tollens reagent
or Fehling's sol.
Gluconic acidPresence of –CHO
4)Strong oxidationConc.HNO3Saccharic acidPresence of –CH2OH
5)ReductionHI/Red 'P'n-HexanePresence of six carbons in
a straight chain

Points in favour of cyclic structure:
1) It doesn't react with schiff's base, NH3&NaHSO3
2) It forms two isomeric glucosides
3) It exhibits mutarotation
Conclusions : From all above points and based on other reactions, it is known that glucose in water exist as a mixture of open chain & ring structures in equilibrium i.e.,

Question Image
Open chain and cyclic structures of α –D–(+)– glucose :
Question Image

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