The accessibility of RNA polymerase to promoter regions of bacterial DNA in many cases is regulated by the interaction of proteins with sequences of the operon termed as
The products of regulatory genes may be either activators that promote the binding of RNA polymerase to the promoter of structural genes or repressors which bind to the sequences known as operators usually present after promoter. Repressors bind to the operator sequences and bring about some conformational change at the promoter and prevent the binding of RNA polymerase to the promoter.