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Q.

Choose the correct statement with respect to works of Oswald Avery, Colin MacLeod and Maclyn McCarty.

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a

Protein digesting enzymes did affect transformation

b

RNA digesting enzymes did affect transformation

c

DNA digesting enzymes did not affect transformation

d

The transforming substance was neither RNA nor Protein

answer is D.

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Detailed Solution

Avery et.al worked to determine the biochemical nature of transforming principle in Griffith’s experiments. They purified the biochemicals of heat killed S-strain of Streptococcus pneumoniae to understand which one was responsible for transforming R cells to S cells. They found proteases, RNases did not affect transformation and only DNase could affect transformation (R strain not converted to S strain).
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