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a
A metallic ion cofactor forms coordinate bonds with substrate as well as at active site of enzyme.
b
A prosthetic group is non-protein organic component of an enzyme tightly bound at the active site of an enzyme.
c
Some enzymes do not have cofactors
d
A coenzyme is tightly bound to the active site of enzyme.
answer is D.
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Detailed Solution
Coenzyme is organic cofactor of a compound enzyme which is loosely bound to the enzyme at the time catalysis at active sites. These have vitamins as their essential chemical components.