First slide

Regulation of Gene Expression

Question

Lac repressor can bind to

Easy

A

only lac operator
B

only beta galactosidase
C

lactose only
D

both operator and lactose.

Solution

Lac repressor is an allosteric protein. It can reversibly bind to both operator (DNA sequence) and to the disaccharide lactose. It has operator binding site and lactose binding site. When bound to lactose, it shows conformational change at the operator binding site and can not bind to or detach from operator. In lactose free conditions, it can bind to operator to prevent transcription of structural genes cluster.

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