First slide

Enzymes

Question

Malic acid inhibits the activity of enzyme succinate dehydrogenase. During this inhibition

Moderate

A

V_max increases, K_m decreases
B

V_max remains the same, K_m decreases
C

V_max decrease, K_m increases
D

V_max remains the same, K_m increases

Solution

Inhibition of succinic dehydrogenase by malonate is an example of competitive inhibition. Malonate closely resembles the substrate succinate in structure. In competitive inhibition V_max remains the same and K_m increases.

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