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Rudolf Virchow first explained that cells divide and new cells are formed from pre-existing cells (Omnis cellula-e cellula).An improved model of the structure of cell membrane was proposed by Singer and Nicolson (1972) widely accepted as fluid mosaic model.Ribosomes are the granular structures first observed under the electron microscope as dense particles by George Palade (1953).Material of the nucleus stained with the basic dyes was given the name chromatin by Flemming.