Q.

The number of decarboxylations that occur in one turn of citric acid cycle is:

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a

Two

b

Three

c

Four

d

Six

answer is A.

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Detailed Solution

In Krebs cycle there is two successive steps of decarboxylation, leading to the formation of α-ketoglutaric acid and then succinyl-CoA. The conversions are as followsIsocitrate (6C) →α-ketoglutarate (5C) + CO2α-ketoglutarate (5C) → Succinyl CoA(4C) + CO2
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