Operon model for gene regulation in prokaryotes was proposed by
Jacob and Monod provided operon model to understand gene regulation in prokaryotes upon carrying out experiments in E. coli. Beadle and Tatum provided one gene one enzyme hypothesis upon carrying experiments in Neurospora crassa. Watson and Crick gave a model for semiconservative replication of DNA and DNA structure. Hershey and Chase established DNA as genetic material in Bacteriophages